Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
نویسندگان
چکیده
منابع مشابه
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.
The ATM protein kinase is activated by intermolecular autophosphorylation in response to DNA damage and initiates cellular signaling pathways that facilitate cell survival and reduce chromosomal breakage. Here, we show that NBS1 and BRCA1 are required for the recruitment of previously activated ATM to the sites of DNA breaks after ionizing irradiation, and that this recruitment is required for ...
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ATMIN defines an NBS1-independent pathway of ATM signalling.
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2004
ISSN: 0890-9369
DOI: 10.1101/gad.1200304